Gestational diabetes affects the mother and their offspring. The underlying cause is not clear. Conventionally, it is assumed to be caused by insulin resistance: pregnancy hormones mediate body cell pathways to minimize glucose absorption. Since it is an assumption, neither patients nor doctors can prove it right or wrong.
That is the tragedy to use an assumption in research. Insulin hormones are the keys that unlock cell gateways for glucose absorption. In gestational diabetes, the key-and-lock chain malfunctions. This assumption limits the research on the locks only. What happens if the keys are defective? We have to think outside the box, we need a hypothesis.